LIG1 syndrome mutations remodel a cooperative network of ligand binding interactions to compromise ligation efficiency
نویسندگان
چکیده
منابع مشابه
assessment of the efficiency of s.p.g.c refineries using network dea
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Statistical mechanics applied to cooperative ligand binding to proteins.
By using the lattice statistical argument, we have shown that for a protein whose subunits have the same number of neighbors, the three parameters (K(AB), K(BB), and K(S)K(t)) in the sequential theory formulated by Koshland, Nemethy, and Filmer [Biochemistry (1966) 5, 365] can be reduced to two parameters. One of the parameters, Z, measures the strength of the subunit interactions and is relate...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2021
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkaa1297